The OECD has released new guidance covering toxicokinetic testing of nanoparticles and other particulate materials. The document addresses key issues such as particle dissolution, aggregation, biotransformation and exposure route, helping to strengthen the assessment of nanomaterial behaviour in biological systems.
OECD Issues New Guidance on Toxicokinetics Testing for Nanoparticles
NIA Staff
1 min read
Summary
The OECD has published new guidance on toxicokinetics testing designed to address the specific characteristics of manufactured nanoparticles and other poorly soluble particulate materials.
The document provides recommendations on study design, analytical methods and reporting requirements for oral and inhalation studies. It also outlines the factors that can influence the absorption, distribution, transformation and clearance of particles in biological systems, including dissolution, agglomeration, aggregation and surface properties.
By addressing behaviours that differ from those observed for conventional chemicals, the guidance aims to improve the consistency and scientific relevance of toxicokinetic studies involving nanomaterials and other particulate substances.
Source: OECD, Guidance Document on Toxicokinetics to Accommodate Testing of (Nano)particles
