The OECD is seeking input on how to standardize safety testing for nanomaterials that enter the body through food, drugs, and consumer products.
The draft guidance tackles a poorly understood area: how nano and microparticles dissolve, transform, and get absorbed as they move through the digestive system.
Regulators, industry, and academics all have a stake in the outcome, with harmonized protocols set to reshape toxicokinetic assessments globally.
OECD Opens Public Consultation on Draft Guidance for In Vitro Testing of Orally Ingested Nanomaterials
NIA Staff
1 min read
Summary
The OECD has opened a public consultation on draft guidance for in vitro testing methods that assess the intestinal fate of orally ingested nanomaterials, running from 29 September to 10 November 2025. The guidance document addresses critical aspects of nanomaterial behavior in the human digestive system, including simulation of gastrointestinal digestion and interactions with the intestinal mucosa.
The draft guidance aims to standardize testing approaches for predicting how nano- and microparticles dissolve, transform, and are absorbed following oral ingestion. By establishing harmonized methods, the document will support regulatory agencies in conducting more accurate toxicokinetic assessments and exposure evaluations for nanomaterials that enter the body through ingestion.
